Gold Member Since 2016
Lanzport Biotechnology Co., Ltd.

Lgd-4033, Ligandrol, Ostarine manufacturer / supplier in China, offering 100% Pass Customs Sarms Powder Ostarine Mk-2866, Anabolic Steroid Powder Testosterone Enanthate CAS 315-37-7, Safe Delivery 99.6% Steroid Hormone Testosterone Acetate and so on.

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100% Pass Customs Sarms Powder Ostarine Mk-2866

FOB Price: US $1-10 / g
Min. Order: 10 g
Min. Order FOB Price
10 g US $1-10/ g
Get Latest Price
Port: Shanghai, China
Production Capacity: 5000kg/Month
Payment Terms: L/C, T/T, Western Union, Paypal, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 841205-47-8
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • Appearance: White Powder
  • Transport Package: Discreet Packing Styles
  • Origin: China
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Solid
  • Package: Discreet Package to Pass Customs
  • Trademark: Lanzport
  • Specification: discreet package
Product Description

Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE 
CAS: 2627-69-2 
EINECS: 220-097-5 
Molecular Formula: C9H14N4O5 
Molecular Weight: 258.23 
Assay: 98% 
Apperance: White or off-white powder. 
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases
100% Pass Customs Sarms Powder Ostarine Mk-2866

Functions:
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
 
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
 
 
Biological Activity:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. 
 
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.  
 
 
Specification:
 



Item

Specification

Result

Appearance

 
White powder

Complies

Related substance (HPLC)

Total impurity ≤0.5%
Max single impurity ≤0.1%

0.2%
0.06%

Odor

Characteristic

Complies

Assay

99%

99.8%

Sieve analysis

100% pass 80 mesh

Complies

Loss on Drying
Residue on Ignition

≤1.0%
≤1.0%

0.12%
0.09%

Heavy Metal

<10ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

Residual Solvents

<100ppm

Complies

Residual Pesticide

Negative

Complies

Microbiology

 

 

Total Plate Count

<1000cfu/g

Complies

Yeast & Mold

<100cfu/g

Complies

E.Coli

Negative

Complies

Salmonella

Negative

Complies

 

 

 

Make an order:Please make clear the quantity
Mini Order:1kg
Quote:Prices confirm
Payment ways:Bank Transfer, Western Union, Money Gram and Bitcoin
Delivery ways:All Express Modes(EMS, DHL, TNT, FedEx, UPS,TOll etc.)
Shipping address:Provide your Valid and Correct destination address info(if possible with post code, phone number).
Packing:Select best ways according to quantity and safety degree(Super discreet, professional and experienced)
Lead time:Within 12 hours upon receipt of payment
Package pictures:Photos of parcel would be offered to tell apart the items
Tracking number:Offered once it is released
Shipping time:3-7 working days (Door-to-Door)
After-sale service:24/7 Online for any problems


100% Pass Customs Sarms Powder Ostarine Mk-2866
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